What is meningococcal disease?
Meningococcal disease is caused by bacteria called Neisseria meningitidis. It can lead to serious blood infections. When the linings of the brain and spinal cord become infected, it is called meningitis. The disease strikes quickly and can have serious complications, including death.
What is the shape of Neisseria meningitidis?
meningitidis are gram-negative, coffee-bean shaped diplococci that may occur intracellularly or extracellularly in PMN leukocytes. N.
What is major cockle rash?
Meningococcal meningitis is a rare but serious bacterial infection. It causes the membranes that cover the brain and spinal cord to become inflamed. Each year, approximately 1,000 people in the U.S. get meningococcal disease, which includes meningitis and septicemia (blood infection).
What is meningococcal B?
Meningitis B is one type of meningococcal disease (frequently referred to as meningitis) caused by the bacteria Neisseria meningitidis. Meningitis can attack the brain and spinal cord and cause swelling in those areas as well as a serious infection of the bloodstream, called septicemia.
What are the effects of meningococcal?
Signs and symptoms of meningococcal disease usually start suddenly and include fever, headache, and a stiff neck. It can start with symptoms similar to influenza (flu). Often people with meningococcal disease also have nausea, vomiting, increased sensitivity to light, rash, and confusion.
Is Neisseria meningitidis intracellular or extracellular?
To cause meningitis the extracellular pathogen Neisseria meningitidis has to traverse the blood-cerebrospinal fluid (B-CSF) barrier. Postulating a transcellular passage, meningococci (MC) have been shown to adhere to and enter B-CSF barrier forming human brain microvascular endothelial cells (HBMEC).
What is the antigen contained in nimenrix?
Each 0.5 mL reconstituted dose contains: 5 µg meningococcal polysaccharide serogroup A. 5 µg meningococcal polysaccharide serogroup C. 5 µg meningococcal polysaccharide serogroup W.
How many groups of Meningococci are there?
The meningococcus has 12 serogroups, with A,B,C,W,X,and Y causing most meningitis.
What are the symptoms of meningococcus?
Meningococci can also cause other problems, including a serious bloodstream infection called sepsis. In its early stages, you may have flu-like symptoms and a stiff neck. But the disease can progress quickly and can be fatal. Early diagnosis and treatment are extremely important.
What is the pathophysiology of bacterial meningococcus (meningococcus) infection?
Meningococcal infection is typical anthroponosis. The sourses of infection are healthy carriers of meningococcus, the patients with meningococcal nasopharingitis and the patients with generalized forms of the disease. The patients with generalized form are more dangerous.
What is the global prevalence of meningococcal infections?
Meningococcal infections occur worldwide and are notifiable in most countries. About two-thirds of cases occur in the first 5 years of life. The larger part of carriers is reveled among adults. The morbidity is higher in the towns. The incidence of meningococcal infection is increasing. Acute meningitis causes about 150000 deaths per year.
Who are the best authors on meningococcal disease?
Shamez N. Ladhani, Jay Lucidarme, Lynne S. Newbold, Stephen J. Gray, Anthony D. Carr, Jamie Findlow, Mary E. Ramsay, Edward B. Kaczmarski, and Raymond Borrow What is meningococcal disease? Infection by the bacterium Neisseria meningitidis(meningococcus). Can infect normally sterile sites, causing invasive disease.
